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Diagnostic Value of Adenosine Deaminase Level for the Differential Diagnosis of Tuberculosis and Malignancy in Exudative Lymphocytic Pleurisy

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dc.contributor.author Altinsoy, Bulent
dc.contributor.author Yalcinsoy, Murat
dc.contributor.author Unver, Edhem
dc.contributor.author Gungor, Sinem
dc.contributor.author Mihmanli, Aydanur
dc.contributor.author Akkaya, Esen
dc.date.accessioned 2019-09-11T12:51:43Z
dc.date.available 2019-09-11T12:51:43Z
dc.date.issued 2016
dc.identifier.citation Altinsoy, B. Yalcinsoy, M. Unver, E . Gungor, S . Mihmanli, A . Akkaya, E. (2016). Diagnostic Value of Adenosine Deaminase Level for the Differential Diagnosis of Tuberculosis and Malignancy in Exudative Lymphocytic Pleurisy.Cilt:17. Sayı:2. 59-63 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/13997
dc.description.abstract Objective: To evaluate the diagnostic performance of adenosine deaminase (ADA) levels in patients with exudative lymphocytic pleurisy for the differential diagnosis of tuberculous pleurisy (TBP) and malignant pleural effusion (MPE). Methods: Data on patients with exudative lymphocytic pleurisy were retrospectively analyzed. The study population comprised 54 patients. Thirty-seven were diagnosed with TBP and 17 were diagnosed with MPE. Results: Significant differences were determined in terms of age and ADA, total protein, albumin, and LDH levels between the TBP and MPE groups. The optimal cut-off value of ADA levels was 35.1 U/L for diagnosing TBP. Sensitivity and specificity were 92% and 100%, respectively. Logistic regression analysis was performed to assess independent variables associated with TBP. Independent predictive factors in the model were ADA (OR: 1.21, 95% CI: 1.06-1.39, p=0.006)], and (OR: 0.92, 95% CI: 0.84-1.00, p=0.052)]. The AUC value by the regression equation was 0.979 (p<0.001). When patients were categorized according to age (<50 ve >= 50), two different cut-off values (> 13.51 and > 35.1) for each age range were found in all, but one, TBP patients. Conclusion: ADA levels are useful for the diagnosis of TBP in cases where pleural biopsy cannot be performed or that are inconclusive in making a diagnosis of TBP. In this group, reducing the conventional cut-off value and/or performing an age-based approach seems to improve the diagnostic performance of ADA levels. tr_TR
dc.language.iso eng tr_TR
dc.publisher Aves, buyukdere cad 105-9, mecıdıyekoy, sıslı, ıstanbul 34394, turkey tr_TR
dc.relation.isversionof 10.5152/imj.2016.34735 tr_TR
dc.rights info:eu-repo/semantics/restrictedAccess tr_TR
dc.subject Predıctıve models tr_TR
dc.subject effusıons tr_TR
dc.subject fluıd tr_TR
dc.subject cancer tr_TR
dc.title Diagnostic Value of Adenosine Deaminase Level for the Differential Diagnosis of Tuberculosis and Malignancy in Exudative Lymphocytic Pleurisy tr_TR
dc.type article tr_TR
dc.relation.journal Istanbul medıcal journal tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 17 tr_TR
dc.identifier.issue 2 tr_TR
dc.identifier.startpage 59 tr_TR
dc.identifier.endpage 63 tr_TR


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