İnönü Akademik Arşiv Sistemi

Protective effects of melatonin on renal failure in pinealectomized rats

Basit öğe kaydını göster Parlakpınar, Hakan Acet, Ahmet Gül, Ahmet Altınöz, Eyyüb Eşrefoğlu, Mukaddes Çolak, Cemil 2018-01-11T12:59:23Z 2018-01-11T12:59:23Z 2007
dc.identifier.citation Parlakpınar, H., Acet, H. A., Gül, M., Altınöz, E., Eşrefoğlu, M., & Çolak, C. (2007). Protective Effects Of Melatonin On Renal Failure İn Pinealectomized Rats. International Journal Of Urology, 14(8), 743–748. tr_TR
dc.description International Journal of Urology, 14(8), 743–748. tr_TR
dc.description.abstract Aim: The purpose of the current study was to investigate the effects melatonin on renal function.Methods: The histological appearance of the kidney and malondialdehyde, nitric oxide, glutathione and superoxide dismutase contents weredetermined. Serum creatinine and blood urea nitrogen levels were also assayed. Rats were divided as: Sham, pinealectomized (Px) andpinealectomized and treated with melatonin.Results: In Px group, malondialdehyde and nitric oxide levels were elevated when compared with the sham group. The Px group exhibitedreduced superoxide dismutase activity and glutathione content. All of these harmful changes were restored by melatonin. Melatonin alsoameliorated serum creatinine and blood urea nitrogen levels related to renal injury. The score for glomerular, tubular and interstitial changes wassignificantly higher in the Px group. Melatonin supplementation significantly reduced these parameters.Conclusions: This protective effect may be associated with both melatonin’s lipophilic and hydrophilic effects, thus providing on-site protec-tion against free radical mediated damage. tr_TR
dc.language.iso eng tr_TR
dc.publisher International Journal of Urology tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Aging tr_TR
dc.subject Kidney tr_TR
dc.subject Melatonin tr_TR
dc.subject Pineal gland tr_TR
dc.subject Rat tr_TR
dc.subject Reactive oxygen radical tr_TR
dc.title Protective effects of melatonin on renal failure in pinealectomized rats tr_TR
dc.type article tr_TR
dc.relation.journal International Journal of Urology tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.contributor.authorID 102000 tr_TR
dc.contributor.authorID 107062 tr_TR
dc.contributor.authorID 30868 tr_TR
dc.contributor.authorID 9712 tr_TR
dc.identifier.volume 14 tr_TR
dc.identifier.issue 8 tr_TR
dc.identifier.startpage 743 tr_TR
dc.identifier.endpage 748 tr_TR

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